The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex
Abstract
Analysis of the heteromeric DNA binding protein GABP has revealed the interaction of two distinct peptide sequence motifs normally associated with proteins located in different cellular compartments. The α subunit of GABP contains an 85-amino acid segment related to the Ets family of DNA binding proteins. The ETS domain of GABPα facilitates weak binding to DNA and, together with an adjacent segment of 37 amino acids, mediates stable interaction with GABPβ. The β subunit of GABP contains four imperfect repeats of a sequence present in several transmembrane proteins including the product of the Notch gene of Drosophila melanogaster . These amino-terminal repeats of GABPβ mediate stable interaction with GABPα and, when complexed with GABPα, directly contact DNA. These observations provide evidence for a distinct biochemical role for the 33-amino acid repeats, and suggest that they may serve as a module for the generation of specific dimerization interfaces.
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The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Self-citationThe ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence.
Karim, F. D., Urness, L. D., Thummel, C. S., Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., Maki, R. A., Gunther, C. V., & Nye, J. A. (1990) · Genes & Development · doi:10.1101/gad.4.9.1451 · Cited by 499
The PU.1 transcription factor is the product of the putative oncogene Spi-1
Goebl, M. G. (1990) · Cell · doi:10.1016/0092-8674(90)90676-6 · Cited by 120
Cited by
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
Voges, D., Zwickl, P., & Baumeister, W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.1015 · Cited by 1,608
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243
Virbasius, J. V., & Scarpulla, R. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1309 · Cited by 819
Metadata
- Authors
- Thompson, C. C., Brown, T. A., & McKnight, S. L.
- Venue
- Science
- Published
- 1991-08-16
- Volume
- 253
- Issue
- 5021
- Pages
- 762-768
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989475423
- Cited by
- 455
- References
- 3
- FWCI
- 24.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thompson, C. C., Brown, T. A., & McKnight, S. L. (1991). Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex. Science. https://doi.org/10.1126/science.1876833
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