The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of Ets- and Notch-Related Subunits in GA Binding Protein
Abstract
Recombinant cDNA clones that encode two distinct subunits of the transcription factor GA binding protein (GABP) have been isolated. The predicted amino acid sequence of one subunit, GABPα, exhibits similarity to the sequence of the product of the ets -1 protooncogene in a region known to encompass the Ets DNA binding domain. The sequence of the second subunit, GABPβ, contains four 33-amino acid repeats located close to the NH2-terminus of the subunit. The sequences of these repeats are similar to repeats in several transmembrane proteins, including Notch from Drosophila melanogaster and Glp-1 and Lin-12 from Caenorhabditis elegans . Avid, sequence-specific binding to DNA required the presence of both polypeptides, revealing a conceptual convergence of nuclear transforming proteins and membrane-anchored proteins implicated in developmentally regulated signal transduction processes.
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Cites
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Self-citationThe ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence.
Karim, F. D., Urness, L. D., Thummel, C. S., Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., Maki, R. A., Gunther, C. V., & Nye, J. A. (1990) · Genes & Development · doi:10.1101/gad.4.9.1451 · Cited by 499
The PU.1 transcription factor is the product of the putative oncogene Spi-1
Goebl, M. G. (1990) · Cell · doi:10.1016/0092-8674(90)90676-6 · Cited by 120
Cited by
Schoenherr, C. J., & Anderson, D. J. (1995) · Science · doi:10.1126/science.7871435 · Cited by 976
Virbasius, J. V., & Scarpulla, R. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1309 · Cited by 819
The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
Bell, R. J. A., Rube, H. T., Kreig, A., Mancini, A., Fouse, S. D., Nagarajan, R. P., Choi, S., Hong, C., He, D., Pekmezci, M., et al. (2015) · Science · doi:10.1126/science.aab0015 · Cited by 566
Nye, J. A., Petersen, J. M., Gunther, C. V., Jonsen, M. D., & Graves, B. J. (1992) · Genes & Development · doi:10.1101/gad.6.6.975 · Cited by 363
Specificity within the ets Family of Transcription Factors
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60738-1 · Cited by 344
Metadata
- Authors
- LaMarco, K., Thompson, C. C., Byers, B. P., Walton, E. M., & McKnight, S. L.
- Venue
- Science
- Published
- 1991-08-16
- Volume
- 253
- Issue
- 5021
- Pages
- 789-792
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064657203
- Cited by
- 343
- References
- 3
- FWCI
- 17.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- LaMarco, K., Thompson, C. C., Byers, B. P., Walton, E. M., & McKnight, S. L. (1991). Identification of Ets- and Notch-Related Subunits in GA Binding Protein. Science. https://doi.org/10.1126/science.1876836
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