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Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy Lesions
Abstract
The immunological mechanisms required to engender resistance have been defined in few infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents clinically as a spectrum in which resistance correlates with cell-mediated immunity to the pathogen. To assess in situ cytokine patterns, messenger RNA extracted from leprosy skin biopsy specimens was amplified by the polymerase chain reaction with 14 cytokine-specific primers. In lesions of the resistant form of the disease, messenger RNAs coding for interleukin-2 and interferon-γ were most evident. In contrast, messenger RNAs for interleukin-4, interleukin-5, and interleukin-10 predominated in the multibacillary form. Thus, resistance and susceptibility were correlated with distinct patterns of cytokine production.
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Cited by
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., & Lepper, H. (1995) · Nature · doi:10.1038/373255a0 · Cited by 662
Scharton, T. M., & Scott, P. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.2.567 · Cited by 608
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
Murphy, E., Shibuya, K., Hosken, N., Openshaw, P., Maino, V, Davis, K., Murphy, K., & O'Garra, A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.901 · Cited by 435
Cytokine production at the site of disease in human tuberculosis
Barnes, P. F., Lu, S., Abrams, J. S., Wang, E., Yamamura, M., & Modlin, R. L. (1993) · Infection and Immunity · doi:10.1128/iai.61.8.3482-3489.1993 · Cited by 371
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Metadata
- Authors
- Yamamura, M., Uyemura, K., Deans, R. J., Weinberg, K., Rea, T. H., Bloom, B. R., & Modlin, R. L.
- Venue
- Science
- Published
- 1991-10-11
- Volume
- 254
- Issue
- 5029
- Pages
- 277-279
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976213001
- Cited by
- 1,126
- References
- 0
- FWCI
- 64.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yamamura, M., Uyemura, K., Deans, R. J., Weinberg, K., Rea, T. H., Bloom, B. R., & Modlin, R. L. (1991). Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy Lesions. Science. https://doi.org/10.1126/science.1925582
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