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Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited Disease
Abstract
Guanosine 3′,5′-monophosphate (cyclic GMP) metabolism in developing eye rudiments of Xenopus laevis embryos in culture is disrupted by the phosphodiesterase inhibitor isobutylmethylxanthine. At low concentrations of inhibitor the rudiments develop normally, but at higher concentrations of the inhibitor, cyclic GMP accumulates in the rudiments and the retinal photoreceptor cells degenerate selectively. The isobutylmethylxanthine-induced photoreceptor degeneration is associated with an accumulation of cyclic GMP and, in this respect, it simulates an early biochemical defect in the inherited degenerative disease of rd mice.
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Cited by
Endogenous nitric oxide: physiology, pathology and clinical relevance
MONCADA, S., & HIGGS, E. A. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01383.x · Cited by 759
Circadian photoreception in the retinally degenerate mouse (rd/rd)
Foster, R. G., Provencio, I., Hudson, D., Fiske, S., De Grip, W., & Menaker, M. (1991) · Journal of Comparative Physiology A · doi:10.1007/bf00198171 · Cited by 508
Localization of nitric oxide synthase in the adult rat brain
Rodrigo, J., Springall, D. R., Uttenthal, O., Bentura, M. L., Abadia-Molina, F., Riveros-Moreno, V., Martínez-Murillo, R., Polak, J. M., & Moncada, S. (1994) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1994.0096 · Cited by 377
McLaughlin, M. E., Ehrhart, T. L., Berson, E. L., & Dryja, T. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3249 · Cited by 288
Huang, S. H., Pittler, S. J., Huang, X., Oliveira, L., Berson, E. L., & Dryja, T. P. (1995) · Nature Genetics · doi:10.1038/ng1295-468 · Cited by 253
Metadata
- Authors
- Lolley, R. N., Farber, D. B., Rayborn, M. E., & Hollyfield, J. G.
- Venue
- Science
- Published
- 1977-05-06
- Volume
- 196
- Issue
- 4290
- Pages
- 664-666
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987834587
- Cited by
- 232
- References
- 0
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lolley, R. N., Farber, D. B., Rayborn, M. E., & Hollyfield, J. G. (1977). Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited Disease. Science. https://doi.org/10.1126/science.193183
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
