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Cloning and Expression of a Cocaine-Sensitive Rat Dopamine Transporter
Abstract
The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and γ-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.
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Cited by
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
Neurotransmitter Transporters: Recent Progress
Amara, S. G., & Kuhar, M. J. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.000445 · Cited by 1,082
Self-citationPlasma membrane monoamine transporters: structure, regulation and function
Torres, G. E., Gainetdinov, R. R., & Caron, M. G. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1008 · Cited by 939
A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter
Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 594
Glycine transporters are differentially expressed among CNS cells
Zafra, F., Aragon, C., Olivares, L., Danbolt, N., Gimenez, C., & Storm-Mathisen, J. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03952.1995 · Cited by 521
Metadata
- Authors
- Kilty, J. E., Lorang, D., & Amara, S. G.
- Venue
- Science
- Published
- 1991-10-25
- Volume
- 254
- Issue
- 5031
- Pages
- 578-579
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083674889
- Cited by
- 594
- References
- 0
- FWCI
- 19.51
- Type
- journal article
- Language
- en
- Open access
- closed
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