The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Three-Dimensional Structure of Canine Parvovirus and Its Functional Implications
Abstract
The three-dimensional atomic structure of a single-stranded DNA virus has been determined. Infectious virions of canine parvovirus contain 60 protein subunits that are predominantly VP-2. The central structural motif of VP-2 has the same topology (an eight-stranded antiparallel β barrel) as has been found in many other icosahedral viruses but represents only about one-third of the capsid protein. There is a 22 angstrom (Å) long protrusion on the threefold axes, a 15 Å deep canyon circulating about each of the five cylindrical structures at the fivefold axes, and a 15 Å deep depression at the twofold axes. By analogy with rhinoviruses, the canyon may be the site of receptor attachment. Residues related to the antigenic properties of the virus are found on the threefold protrusions. Some of the amino termini of VP-2 run to the exterior in full but not empty virions, which is consistent with the observation that some VP-2 polypeptides in full particles can be cleaved by trypsin. Eleven nucleotides are seen in each of 60 symmetry-related pockets on the interior surface of the capsid and together account for 13 percent of the genome.
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Citations
Cites
The three-dimensional structure of the bacterial virus MS2
Valegård, K., Liljas, L., Fridborg, K., & Unge, T. (1990) · Nature · doi:10.1038/345036a0 · Cited by 411
Cited by
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
Xie, Q., Bu, W., Bhatia, S., Hare, J., Somasundaram, T., Azzi, A., & Chapman, M. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162250899 · Cited by 612
Self-citationGenetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2
Girod, A., Ried, M., Wobus, C., Lahm, H., Leike, K., Kleinschmidt, J., Deléage, G., & Hallek, M. (1999) · Nature Medicine · doi:10.1038/12491 · Cited by 405
Halbert, C. L., Rutledge, E. A., Allen, J. M., Russell, D. W., & Miller, A. D. (2000) · Journal of Virology · doi:10.1128/jvi.74.3.1524-1532.2000 · Cited by 259
Moskalenko, M., Chen, L., van Roey, M., Donahue, B. A., Snyder, R. O., McArthur, J. G., & Patel, S. D. (2000) · Journal of Virology · doi:10.1128/jvi.74.4.1761-1766.2000 · Cited by 253
Functional implications of the structure of the murine parvovirus, minute virus of mice
Agbandje-McKenna, M., Llamas-Saiz, A. L., Wang, F., Tattersall, P., & Rossmann, M. G. (1998) · Structure · doi:10.1016/s0969-2126(98)00137-3 · Cited by 218
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Metadata
- Authors
- Tsao, J., Chapman, M. S., Agbandje, M., Keller, W., Smith, K., Wu, H., Luo, M., Smith, T. J., Rossmann, M. G., Compans, R. W., & Parrish, C. R.
- Venue
- Science
- Published
- 1991-03-22
- Volume
- 251
- Issue
- 5000
- Pages
- 1456-1464
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082890587
- Cited by
- 512
- References
- 1
- FWCI
- 25.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tsao, J., Chapman, M. S., Agbandje, M., Keller, W., Smith, K., Wu, H., Luo, M., Smith, T. J., Rossmann, M. G., Compans, R. W., & Parrish, C. R. (1991). The Three-Dimensional Structure of Canine Parvovirus and Its Functional Implications. Science. https://doi.org/10.1126/science.2006420
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