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Modular Organization of Genes Required for Complex Polyketide Biosynthesis
Abstract
In Saccharopolyspora erythraea , the genes that govern synthesis of the polyketide portion of the macrolide antibiotic erythromycin are organized in six repeated units that encode fatty acid synthase (FAS)-like activities. Each repeated unit is designated a module, and two modules are contained in a single open reading frame. A model for the synthesis of this complex polyketide is proposed, where each module encodes a functional synthase unit and each synthase unit participates specifically in one of the six FAS-like elongation steps required for formation of the polyketide. In addition, genetic organization and biochemical order of events appear to be colinear. Evidence for the model is provided by construction of a selected mutant and by isolation of a polyketide of predicted structure.
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Citations
Cited by
Polyketide biosynthesis: a millennium review
Staunton, J., & Weissman, K. J. (2001) · Natural Product Reports · doi:10.1039/a909079g · Cited by 1,641
Bacterial resistance to antibiotics: Enzymatic degradation and modification
WRIGHT, G. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.04.002 · Cited by 897
Genetic Contributions to Understanding Polyketide Synthases
Hopwood, D. A. (1997) · Chemical Reviews · doi:10.1021/cr960034i · Cited by 710
Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms
Shen, B. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(03)00020-6 · Cited by 565
Belanger, A. E., Besra, G. S., Ford, M. E., Mikusová, K., Belisle, J. T., Brennan, P. J., & Inamine, J. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11919 · Cited by 466
Metadata
- Authors
- Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J., & Katz, L.
- Venue
- Science
- Published
- 1991-05-03
- Volume
- 252
- Issue
- 5006
- Pages
- 675-679
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993274596
- Cited by
- 898
- References
- 0
- FWCI
- 42.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Modular Organization of Genes Required for Complex Polyketide Biosynthesis. https://app.cochat.ai/papers/10.1126/science.2024119
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- Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J., & Katz, L. (1991). Modular Organization of Genes Required for Complex Polyketide Biosynthesis. Science. https://doi.org/10.1126/science.2024119
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
