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A New Redox Cofactor in Eukaryotic Enzymes: 6-Hydroxydopa at the Active Site of Bovine Serum Amine Oxidase
Abstract
An active site, cofactor-containing peptide has been obtained in high yield from bovine serum amine oxidase. Sequencing of this pentapeptide indicates: Leu-Asn-X-Asp-Tyr. Analysis of the peptide by mass spectrometry, ultraviolet-visible spectroscopy, and proton nuclear magnetic resonance leads to the identification of X as 6-hydroxydopa. This result indicates that, contrary to previous proposals, pyrroloquinoline quinone is not the active site cofactor in mammalian copper amine oxidases. Although 6-hydroxydopa has been implicated in neurotoxicity, the data presented suggest that this compound has a functional role at an enzyme active site.
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Cited by
Xie, H., Vucetic, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Obradovic, Z., & Uversky, V. N. (2007) · Journal of Proteome Research · doi:10.1021/pr060394e · Cited by 382
Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues
Novotny, W. F., Chassande, O., Baker, M., Lazdunski, M., & Barbry, P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36970-3 · Cited by 93
Status of, and developments in, mass spectrometry of peptides and proteins
Roepstorff, P., & Richter, W. J. (1992) · International Journal of Mass Spectrometry and Ion Processes · doi:10.1016/0168-1176(92)85085-e · Cited by 15
Metadata
- Authors
- Janes, S. M., Mu, D., Wemmer, D., Smith, A. J., Kaur, S., Maltby, D., Burlingame, A. L., & Klinman, J. P.
- Venue
- Science
- Published
- 1990-05-25
- Volume
- 248
- Issue
- 4958
- Pages
- 981-987
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069350944
- Cited by
- 659
- References
- 0
- FWCI
- 53.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A New Redox Cofactor in Eukaryotic Enzymes: 6-Hydroxydopa at the Active Site of Bovine Serum Amine Oxidase. https://app.cochat.ai/papers/10.1126/science.2111581
- The paper
- Janes, S. M., Mu, D., Wemmer, D., Smith, A. J., Kaur, S., Maltby, D., Burlingame, A. L., & Klinman, J. P. (1990). A New Redox Cofactor in Eukaryotic Enzymes: 6-Hydroxydopa at the Active Site of Bovine Serum Amine Oxidase. Science. https://doi.org/10.1126/science.2111581
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
