The DOI matches its Crossref record.
Growth Factors Induce Phosphorylation of the Na + /H + Antiporter, a Glycoprotein of 110 kD
Abstract
The Na + /H + antiporter, which regulates intracellular p H in virtually all cells, is one of the best examples of a mitogen- and oncogene-activated membrane target whose activity rapidly changes on stimulation. The activating mechanism is unknown. A Na + /H + antiporter complementary DNA fragment was expressed in Escherichia coli as a β-galactosidase fusion protein, and a specific antibody to the fusion protein was prepared. Use of this antibody revealed that the Na + /H + antiporter is a 110-kilodalton glycoprotein that is phosphorylated in growing cells. Mitogenic activation of resting hamster fibroblasts and A431 human epidermoid cells with epidermal growth factor, thrombin, phorbol esters, or serum, stimulated phosphorylation of the Na + /H + antiporter with a time course similar to that of the rise in intracellular p H.
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Cited by
MOLECULAR PHYSIOLOGY OF INTESTINAL N + /H + EXCHANGE
Zachos, N. C., Tse, M., & Donowitz, M. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.031103.153004 · Cited by 365
Metadata
- Authors
- Sardet, C., Counillon, L., Franchi, A., & Pouysségur, J.
- Venue
- Science
- Published
- 1990-02-09
- Volume
- 247
- Issue
- 4943
- Pages
- 723-726
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091319839
- Cited by
- 449
- References
- 0
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sardet, C., Counillon, L., Franchi, A., & Pouysségur, J. (1990). Growth Factors Induce Phosphorylation of the Na + /H + Antiporter, a Glycoprotein of 110 kD. Science. https://doi.org/10.1126/science.2154036
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