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Steady-State Coupling of Ion-Channel Conformations to a Transmembrane Ion Gradient
Abstract
Under stationary conditions, opening and closing of single Torpedo electroplax chloride channels show that the number of transitions per unit time between inactivated and conducting states are unequal in opposite directions. This asymmetry, which increases with transmembrane electrochemical gradient for the chloride ion, violates the principle of microscopic reversibility and thus demonstrates that the channel-gating process is not at thermodynamic equilibrium. The results imply that the channel's conformational states are coupled to the transmembrane electrochemical gradient of the chloride ion.
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Cited by
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T., & MacKinnon, R. (2002) · Nature · doi:10.1038/415287a · Cited by 1,446
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Gating the Selectivity Filter in ClC Chloride Channels
Dutzler, R., Campbell, E. B., & MacKinnon, R. (2003) · Science · doi:10.1126/science.1082708 · Cited by 727
Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle
Feng, L., Campbell, E. B., Hsiung, Y., & MacKinnon, R. (2010) · Science · doi:10.1126/science.1195230 · Cited by 270
Uncoupling and Turnover in a Cl−/H+ Exchange Transporter
Walden, M., Accardi, A., Wu, F., Xu, C., Williams, C., & Miller, C. (2007) · The Journal of General Physiology · doi:10.1085/jgp.200709756 · Cited by 142
Self-citation
Metadata
- Authors
- Richard, E. A., & Miller, C.
- Venue
- Science
- Published
- 1990-03-09
- Volume
- 247
- Issue
- 4947
- Pages
- 1208-1210
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038794309
- Cited by
- 177
- References
- 0
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Richard, E. A., & Miller, C. (1990). Steady-State Coupling of Ion-Channel Conformations to a Transmembrane Ion Gradient. Science. https://doi.org/10.1126/science.2156338
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
