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Cited by 275

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

The Relationship Between Charge Movements Associated with I Ca and I Na-Ca in Cardiac Myocyte

Bridge, John H. B., Smolley, John R., Spitzer, Kenneth W.·1990·Science
DOI 10.1126/science.2158147
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Abstract

Ventricular myocytes exhibit a nifedipine-sensitive inward calcium current ( I Ca ) and contracture when they are voltage clamped from -40 to 0 millivolt in the presence of caffeine and in the absence of extracellular sodium. However, upon repolarization they fail to relax because neither the sarcoplasmic reticulum nor the sodium-calcium exchange can reduce intracellular calcium. Sudden application of extracellular sodium during the contracture (but after repolarization) causes immediate relaxation and activates a transient inward sodium-calcium exchange current ( I Na-Ca ), whose peak slightly precedes mechanical relaxation. The total charge carried by the nifedipine-sensitive I Ca is twice the total charge carried by the transient inward I Na-Ca . Assuming an exchange stoichiometry of three sodium to one calcium, these results indicate that all the calcium entering the cell during the initial depolarization is extruded by the sodium-calcium exchange.

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Metadata

Authors
Bridge, J. H. B., Smolley, J. R., & Spitzer, K. W.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1990-04-20
Volume
248
Issue
4953
Pages
376-378
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2158147
OpenAlex
W2006036490
Cited by
275
References
15
FWCI
16.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Relationship Between Charge Movements Associated with I Ca and I Na-Ca in Cardiac Myocyte. https://app.cochat.ai/papers/10.1126/science.2158147
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Bridge, J. H. B., Smolley, J. R., & Spitzer, K. W. (1990). The Relationship Between Charge Movements Associated with I Ca and I Na-Ca in Cardiac Myocyte. Science. https://doi.org/10.1126/science.2158147

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.