The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product
Abstract
K rev -1 is known to suppress transformation by ras . However, the mechanism of the suppression is unclear. The protein product of K rev -1, Rap1A-p21, is identical to Ras-p21 proteins in the region where interaction with guanosine triphosphatase (GTPase) activating protein (GAP) is believed to occur. Therefore, the ability of GAP to interact with Rap1A-p21 was tested. Rap1A-p21 was not activated by GAP but bound tightly to GAP and was an effective competitive inhibitor of GAP-mediated Ras-GTPase activity. Binding of GAP to Rap1A-p21 was strictly guanosine triphosphate (GTP)-dependent. The ability of Rap1A-p21 to bind tightly to GAP may account for K rev -1 suppression of transformation by ras . This may occur by preventing interaction of GAP with Ras-p21 or with other cellular proteins necessary for GAP-mediated Ras GTPase activity.
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Citations
Cites
A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants
Trahey, M., & McCormick, F. (1987) · Science · doi:10.1126/science.2821624 · Cited by 1,211
Self-citation
Cited by
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Self-citationMolecular themes in oncogenesis
Bishop, J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90636-d · Cited by 1,637
The neurofibromatosis type 1 gene encodes a protein related to GAP
Xu, G., O'Connell, P., Viskochil, D., Cawthon, R., Robertson, M., Culver, M., Dunn, D., Stevens, J., Gesteland, R., White, R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90024-9 · Cited by 1,095
Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs
de Rooij, J., Rehmann, H., van Triest, M., Cool, R. H., Wittinghofer, A., & Bos, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001113200 · Cited by 398
Self-citationRapid Ca2+-mediated activation of Rap1 in human platelets
Franke, B. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.252 · Cited by 396
Metadata
- Authors
- Frech, M., John, J., Pizon, V., Chardin, P., Tavitian, A., Clark, R., McCormick, F., & Wittinghofer, A.
- Venue
- Science
- Published
- 1990-07-13
- Volume
- 249
- Issue
- 4965
- Pages
- 169-171
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967838053
- Cited by
- 251
- References
- 1
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frech, M., John, J., Pizon, V., Chardin, P., Tavitian, A., Clark, R., McCormick, F., & Wittinghofer, A. (1990). Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product. Science. https://doi.org/10.1126/science.2164710
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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