The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription
Abstract
Phosphoenolpyruvate carboxykinase (PEPCK) governs the rate-limiting step in gluconeogenesis. Glucocorticoids and adenosine 3′,5′-monophosphate (cAMP) increase PEPCK gene transcription and gluconeogenesis, whereas insulin has the opposite effect. Insulin is dominant, since it prevents cAMP and glucocorticoid-stimulated transcription. Glucocorticoid and cAMP response elements have been located in the PEPCK gene and now a 15-base pair insulin-responsive sequence (IRS) is described. Evidence for a binding activity that recognizes this sequence is presented.
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Cites
Sasaki, K., Cripe, T. P., Koch, S. R., Andreone, T. L., Petersen, D. D., Beale, E. G., & Granner, D. K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42541-5 · Cited by 428
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Cited by
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Pancreatic regulation of glucose homeostasis.
Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985
REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION
Hanson, R. W., & Reshef, L. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.581 · Cited by 729
Regulation of glucose homeostasis by glucocorticoids
Kuo, T., McQueen, A., Chen, T.-C., & Wang, J.-C. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-2895-8_5 · Cited by 723
Insulin regulation of gluconeogenesis
Hatting, M., Tavares, C. D. J., Sharabi, K., Rines, A. K., & Puigserver, P. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13435 · Cited by 587
Metadata
- Authors
- O'Brien, R. M., Lucas, P. C., Forest, C. D., Magnuson, M. A., & Granner, D. K.
- Venue
- Science
- Published
- 1990-08-03
- Volume
- 249
- Issue
- 4968
- Pages
- 533-537
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059911808
- Cited by
- 357
- References
- 1
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription. https://app.cochat.ai/papers/10.1126/science.2166335
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- O'Brien, R. M., Lucas, P. C., Forest, C. D., Magnuson, M. A., & Granner, D. K. (1990). Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription. Science. https://doi.org/10.1126/science.2166335
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
