The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Increased Activity of Calcium Leak Channels in Myotubes of Duchenne Human and mdx Mouse Origin
Abstract
Elevated free Ca 2+ concentrations found in adult dystrophic muscle fibers result in enhanced protein degradation. Since the difference in concentrations may reflect differences in entry, Ca 2+ leak channels in cultures of normal and Duchenne human myotubes, and normal and mdx murine myotubes, have been identified and characterized. The open probability of leak channels is markedly increased in dystrophic myotubes. Other channel properties, such as mean open times, single channel conductance, ion selectivity, and behavior in the presence of pharmacological agents, were similar among myotube types. Compared to the Ca 2+ concentrations in normal human and normal mouse myotubes, intracellular resting free Ca 2+ concentrations ([Ca 2+ ] i ) in myotubes of Duchenne and mdx origin were significantly higher at a time when dystrophin is first expressed in normal tissue. Taken together, these findings suggest that the increased open probability of Ca 2+ leak channels contributes to the elevated free intracellular Ca 2+ concentration in Duchenne human and mdx mouse myotubes.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
Cited by
Skeletal muscle fatigue: cellular mechanisms
Allen, D. G., Lamb, G. D., & Westerblad, H. (2008) · Physiological Reviews · doi:10.1152/physrev.00015.2007 · Cited by 2,495
Dystrophin protects the sarcolemma from stresses developed during muscle contraction
Petrof, B. J., Shrager, J. B., Stedman, H. H., Kelly, A. M., & Sweeney, H. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3710 · Cited by 1,526
Function and Genetics of Dystrophin and Dystrophin-Related Proteins in Muscle
Blake, D. J., Weir, A., Newey, S. E., & Davies, K. E. (2002) · Physiological Reviews · doi:10.1152/physrev.00028.2001 · Cited by 1,242
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
Bellinger, A. M., Reiken, S., Carlson, C., Mongillo, M., Liu, X., Rothman, L., Matecki, S., Lacampagne, A., & Marks, A. R. (2009) · Nature Medicine · doi:10.1038/nm.1916 · Cited by 531
Kurebayashi, N., & Ogawa, Y. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0185b.x · Cited by 275
Metadata
- Authors
- Fong, P., Turner, P. R., Denetclaw, W. F., & Steinhardt, R. A.
- Venue
- Science
- Published
- 1990-11-02
- Volume
- 250
- Issue
- 4981
- Pages
- 673-676
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010762668
- Cited by
- 356
- References
- 2
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fong, P., Turner, P. R., Denetclaw, W. F., & Steinhardt, R. A. (1990). Increased Activity of Calcium Leak Channels in Myotubes of Duchenne Human and mdx Mouse Origin. Science. https://doi.org/10.1126/science.2173137
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