The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17
Abstract
Acute promyelocytic leukemia (APL; FAB M3) is characterized by a predominance of malignant promyelocytes that carry a reciprocal translocation between the long arms of chromosomes 15 and 17, t(15;17)(q22;q11.2-q12). This translocation has become diagnostic for APL, as it is present in almost 100 percent of cases. A Not I linking clone was used to detect this translocation initially on pulsed-field gel electrophoresis and subsequently with conventional Southern (DNA) analysis. The breakpoints in ten APL cases examined were shown to cluster in a 12-kb region of chromosome 17, containing two CpG-rich islands. The region is the first intron of the retinoic acid receptor α gene ( RARA ).
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A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
Klein, A. D., Kessel, A. G. V., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J., & Stephenson, J. R. (1982) · Nature · doi:10.1038/300765a0 · Cited by 1,378
Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Kakizuka, A., Miller, W. H., Umesono, K., Warrell, R. P., Frankel, S. R., Murty, V. V. V. S., Dmitrovsky, E., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90112-c · Cited by 1,427
Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)
Warrell, R. P., Frankel, S. R., Miller, W. H., Scheinberg, D. A., Itri, L. M., Hittelman, W. N., Vyas, R., Andreeff, M., Tafuri, A., Jakubowski, A., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199105163242002 · Cited by 1,251
Nuclear structure in cancer cells
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Metadata
- Authors
- Borrow, J., Goddard, A. D., Sheer, D., & Solomon, E.
- Venue
- Science
- Published
- 1990-09-28
- Volume
- 249
- Issue
- 4976
- Pages
- 1577-1580
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974839297
- Cited by
- 632
- References
- 3
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Borrow, J., Goddard, A. D., Sheer, D., & Solomon, E. (1990). Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17. Science. https://doi.org/10.1126/science.2218500
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