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gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein
Abstract
The polymerization of actin filaments is involved in growth, movement, and cell division. It has been shown that actin polymerization is controlled by gelsolin, whose interactions with actin are activated by calcium ion (Ca 2+ ) and inhibited by membrane polyphosphoinositides (PPI). A smaller Ca 2+ - and PPI-regulated protein, gCap39, which has 49% sequence identity with gelsolin, has been identified by cDNA cloning and protein purification. Like gelsolin, gCap39 binds to the fast-growing (+) end of actin filaments. However, gCap39 does not sever actin filaments and can respond to Ca 2+ and PPI transients independently, under conditions in which gelsolin is ineffective. The coexistence of gCap39 with gelsolin should allow precise regulation of actin assembly at the leading edge of the cell.
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Cited by
Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function
Fukami, K., Furuhashi, K., Inagaki, M., Endo, T., Hatano, S., & Takenawa, T. (1992) · Nature · doi:10.1038/359150a0 · Cited by 326
Hartwig, J. H., & Kwiatkowski, D. J. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90170-4 · Cited by 287
Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins
Yu, F. X., Lin, S. C., Morrison-Bogorad, M., Atkinson, M. A., & Yin, H. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54179-x · Cited by 177
Self-citationFitz, N. F., Nam, K. N., Wolfe, C. M., Letronne, F., Playso, B. E., Iordanova, B. E., Kozai, T. D. Y., Biedrzycki, R. J., Kagan, V. E., Tyurina, Y. Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23762-0 · Cited by 129
Hinchliffe (1998) · doi:10.1016/s0005-2760(98)00140-4 · Cited by 110
Metadata
- Authors
- Yu, F.-X., Johnston, P. A., Südhof, T. C., & Yin, H. L.
- Venue
- Science
- Published
- 1990-12-07
- Volume
- 250
- Issue
- 4986
- Pages
- 1413-1415
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972617251
- Cited by
- 225
- References
- 0
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, F.-X., Johnston, P. A., Südhof, T. C., & Yin, H. L. (1990). gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein. Science. https://doi.org/10.1126/science.2255912
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