The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cloning and Expression of a Developmentally Regulated Protein That Induces Mitogenic and Neurite Outgrowth Activity
Abstract
A heparin binding mitogenic protein isolated from bovine uterus shares NH 2 -terminal amino acid sequence with a protein isolated from newborn rat brain. The cDNA's of the bovine, human, and rat genes have been isolated and encode extraordinarily conserved proteins unrelated to known growth or neurotrophic factors, although identity of nearly 50 percent has been found with the predicted sequence of a retinoic acid induced transcript in differentiating mouse embryonal carcinoma cells. Lysates of COS-7 cells transiently expressing this protein were mitogenic for NRK cells and initiated neurite outgrowth from mixed cultures of embryonic rat brain cells. RNA transcripts encoding this protein were widely distributed in tissues and were developmentally regulated. This protein, previously designated as heparin binding growth factor (HBGF)-8, is now renamed pleiotrophin (PTN) to reflect its diverse activities. PTN may be the first member of a family of developmentally regulated cytokines.
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Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
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Cited by
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,208
Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., & Ferrara, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35712-0 · Cited by 1,127
McKeon, R. J., Jurynec, M. J., & Buck, C. R. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-24-10778.1999 · Cited by 480
Neurotrophic protein S100 beta stimulates glial cell proliferation.
Selinfreund, R. H., Barger, S. W., Pledger, W. J., & Van Eldik, L. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3554 · Cited by 323
Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth.
Kinnunen, T., Kaksonen, M., Saarinen, J., Kalkkinen, N., Peng, H. B., & Rauvala, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10702 · Cited by 234
Metadata
- Authors
- Li, Y.-S., Milner, P. G., Chauhan, A. K., Watson, M. A., Hoffman, R. M., Kodner, C. M., Milbrandt, J., & Deuel, T. F.
- Venue
- Science
- Published
- 1990-12-21
- Volume
- 250
- Issue
- 4988
- Pages
- 1690-1694
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074030659
- Cited by
- 474
- References
- 4
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Y.-S., Milner, P. G., Chauhan, A. K., Watson, M. A., Hoffman, R. M., Kodner, C. M., Milbrandt, J., & Deuel, T. F. (1990). Cloning and Expression of a Developmentally Regulated Protein That Induces Mitogenic and Neurite Outgrowth Activity. Science. https://doi.org/10.1126/science.2270483
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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