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Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor
Abstract
Identification of a mutant epidermal growth factor (EGF) receptor that does not undergo downregulation has provided a genetic probe to investigate the role of internalization in ligand-induced mitogenesis. Contact-inhibited cells expressing this internalization-defective receptor exhibited a normal mitogenic response at significantly lower ligand concentrations than did cells expressing wild-type receptors. A transformed phenotype and anchorage-independent growth were observed at ligand concentrations that failed to elicit these responses in cells expressing wild-type receptors. These findings imply that activation of the protein tyrosine kinase activity at the cell membrane is sufficient for the growth-enhancing effects of EGF. Thus, downregulation can serve as an attenuation mechanism, without which transformation ensues.
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Citations
Cited by
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Tall, G. G., Barbieri, M. A., Stahl, P. D., & Horazdovsky, B. F. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00008-9 · Cited by 308
Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor
Swindle, C. S., Tran, K. T., Johnson, T. D., Banerjee, P., Mayes, A. M., Griffith, L., & Wells, A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103103 · Cited by 286
Self-citationStraight, S. W., Hinkle, P. M., Jewers, R. J., & McCance, D. J. (1993) · Journal of Virology · doi:10.1128/jvi.67.8.4521-4532.1993 · Cited by 271
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Metadata
- Authors
- Wells, A., Welsh, J. B., Lazar, C. S., Wiley, H. S., Gill, G. N., & Rosenfeld, M. G.
- Venue
- Science
- Published
- 1990-02-23
- Volume
- 247
- Issue
- 4945
- Pages
- 962-964
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061671663
- Cited by
- 411
- References
- 0
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor. https://app.cochat.ai/papers/10.1126/science.2305263
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- Wells, A., Welsh, J. B., Lazar, C. S., Wiley, H. S., Gill, G. N., & Rosenfeld, M. G. (1990). Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor. Science. https://doi.org/10.1126/science.2305263
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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