The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products
Abstract
Oncogenic activation of the proto-oncogene c- abl in human leukemias occurs as a result of the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of tyrosine kinase activity and quantitative measurement of transformation potency in a single-step assay indicate that variation in bcr exon contribution results in a functional difference between p210 bcr-abl and p185 bcr-abl proteins. Thus, foreign upstream sequences are important in the deregulation of the kinase activity of the abl product, and the extent of deregulation correlates with the pathological effects of the bcr-abl proteins.
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Citations
Cites
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
Klein, A. D., Kessel, A. G. V., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J., & Stephenson, J. R. (1982) · Nature · doi:10.1038/300765a0 · Cited by 1,378
Cited by
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
Druker, B. J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G. M., Fanning, S., Zimmermann, J., & Lydon, N. B. (1996) · Nature Medicine · doi:10.1038/nm0596-561 · Cited by 2,967
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
Jamieson, C. H. M., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040258 · Cited by 1,485
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
The Myeloproliferative Disorders
Campbell, P. J., & Green, A. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmra063728 · Cited by 915
Druker, B. J., & Lydon, N. B. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9083 · Cited by 707
Metadata
- Authors
- Lugo, T. G., Pendergast, A.-M., Muller, A. J., & Witte, O. N.
- Venue
- Science
- Published
- 1990-03-02
- Volume
- 247
- Issue
- 4946
- Pages
- 1079-1082
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040396943
- Cited by
- 1,281
- References
- 1
- FWCI
- 16.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products. https://app.cochat.ai/papers/10.1126/science.2408149
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- Lugo, T. G., Pendergast, A.-M., Muller, A. J., & Witte, O. N. (1990). Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products. Science. https://doi.org/10.1126/science.2408149
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
