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Antigens Induced on Erythrocytes by P. falciparum : Expression of Diverse and Conserved Determinants
Abstract
Red blood cells that are infected with the malaria parasite Plasmodium falciparum express new antigens on their surface. In a study of these antigens in the erythrocytes of naturally infected children in the Gambia, an antibody-mediated agglutination assay revealed an extreme degree of antigenic diversity. Serum samples from each of ten children in the convalescent stage of malaria infection reacted with infected cells from the same child but generally not with infected cells from the other children. The Gambian children's erythrocytes also expressed shared determinants: sera from Gambian adults often reacted with the surface of infected cells from all of the children and were shown by adsorption and elution experiments to contain antibodies that recognized several isolates. Conserved determinants exposed on infected erythrocytes may be important for development of antimalarial immunity either naturally or through vaccination.
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Cited by
Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
Bull, P. C., Lowe, B. S., Kortok, M., Molyneux, C. S., Newbold, C. I., & Marsh, K. (1998) · Nature Medicine · doi:10.1038/nm0398-358 · Cited by 645
Self-citationRapid switching to multiple antigenic and adhesive phenotypes in malaria
Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619
Self-citationMarsh, K., Otoo, L., Hayes, R. J., Carson, D. C., & Greenwood, B. M. (1989) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(89)90478-1 · Cited by 446
Self-citationRicke, C. H., Staalsoe, T., Koram, K., Akanmori, B. D., Riley, E. M., Theander, T. G., & Hviid, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3309 · Cited by 303
Metadata
- Authors
- Marsh, K., & Howard, R. J.
- Venue
- Science
- Published
- 1986-01-10
- Volume
- 231
- Issue
- 4734
- Pages
- 150-153
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083442176
- Cited by
- 322
- References
- 0
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marsh, K., & Howard, R. J. (1986). Antigens Induced on Erythrocytes by P. falciparum : Expression of Diverse and Conserved Determinants. Science. https://doi.org/10.1126/science.2417315
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