The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis
Abstract
In many epithelial cells the chloride conductance of the apical membrane increases during the stimulation of electrolyte secretion. Single-channel recordings from human airway epithelial cells showed that β-adrenergic stimulation evoked apical membrane chloride channel activity, but this response was absent in cells from patients with cystic fibrosis (CF). However, when membrane patches were excised from CF cells into media containing sufficient free calcium (approximately 180 nanomolar), chloride channels were activated. The chloride channels of CF cells were similar to those of normal cells as judged by their current-voltage relations, ion selectivity, and kinetic behavior. These findings demonstrate the presence of chloride channels in the apical membranes of CF airway cells. Their regulation by calcium appears to be intact, but cyclic adenosine monophosphate (cAMP)-dependent control of their activity is defective.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Biology of sweat glands and their disorders. I. Normal sweat gland function
Sato, K., Kang, W. H., Saga, K., & Sato, K. T. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70063-3 · Cited by 717
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Metadata
- Authors
- Frizzell, R. A., Rechkemmer, G., & Shoemaker, R. L.
- Venue
- Science
- Published
- 1986-08
- Volume
- 233
- Issue
- 4763
- Pages
- 558-560
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1973868711
- Cited by
- 562
- References
- 1
- FWCI
- 89.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frizzell, R. A., Rechkemmer, G., & Shoemaker, R. L. (1986). Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis. Science. https://doi.org/10.1126/science.2425436
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
