The DOI matches its Crossref record.
Replacement of Liver Function in Rats by Transplantation of Microcarrier-Attached Hepatocytes
Abstract
Isolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, can be attached to collagen-coated dextran microcarriers and transplanted by intraperitoneal injection into rats. Survival and function of the transplanted hepatocytes have been demonstrated in mutant rats lacking bilirubin-uridine diphosphate glucuronosyltransferase activity (Gunn strain) and rats with inherited lack of plasma albumin (Nagase analbuminemia rat strain). This simple technique promises to be useful in the treatment of acute liver failure in humans.
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Citations
Cited by
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
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Ahmed, T. A. E., Dare, E. V., & Hincke, M. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2007.0435 · Cited by 994
Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels
Tsang, V. L., Chen, A. A., Cho, L. M., Jadin, K. D., Sah, R. L., DeLong, S., West, J. L., & Bhatia, S. N. (2007) · The FASEB Journal · doi:10.1096/fj.06-7117com · Cited by 462
Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes
Kobayashi, N., Fujiwara, T., Westerman, K. A., Inoue, Y., Sakaguchi, M., Noguchi, H., Miyazaki, M., Cai, J., Tanaka, N., Fox, I. J., et al. (2000) · Science · doi:10.1126/science.287.5456.1258 · Cited by 331
Bao, J., Shi, Y., Sun, H., Yin, X., Yang, R., Li, L., Chen, X., & Bu, H. (2011) · Cell Transplantation · doi:10.3727/096368910x536572 · Cited by 133
Metadata
- Authors
- Demetriou, A. A., Whiting, J. F., Feldman, D., Levenson, S. M., Chowdhury, N. R., Moscioni, A. D., Kram, M., & Chowdhury, J. R.
- Venue
- Science
- Published
- 1986-09-12
- Volume
- 233
- Issue
- 4769
- Pages
- 1190-1192
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043300139
- Cited by
- 294
- References
- 0
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Replacement of Liver Function in Rats by Transplantation of Microcarrier-Attached Hepatocytes. https://app.cochat.ai/papers/10.1126/science.2426782
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- Demetriou, A. A., Whiting, J. F., Feldman, D., Levenson, S. M., Chowdhury, N. R., Moscioni, A. D., Kram, M., & Chowdhury, J. R. (1986). Replacement of Liver Function in Rats by Transplantation of Microcarrier-Attached Hepatocytes. Science. https://doi.org/10.1126/science.2426782
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
