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Depolarization Without Calcium Can Release γ-Aminobutyric Acid from a Retinal Neuron
Abstract
Calcium influx is often an essential intermediate step for the release of neurotransmitter. However, some retinal neurons appear to release transmitter by a mechanism that does not require calcium influx. It was uncertain whether depolarization released calcium from an intracellular store or released transmitter by a mechanism that does not require calcium. The possibility that voltage, and not calcium, can regulate the release of transmitter was studied with pairs of solitary retinal neurons. Horizontal and bipolar cells were isolated from fish retinas and juxtaposed in culture. Communication between them was studied with electrophysiological methods. A horizontal cell released its neurotransmitter, γ-aminobutyric acid, when depolarized during conditions that buffered the internal calcium concentration and prohibited calcium entry. The speed and amount of material released were sufficient for a contribution to synaptic transmission.
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Cited by
Nonvesicular release of neurotransmitter
Attwell, D., Barbour, B., & Szatkowski, M. (1993) · Neuron · doi:10.1016/0896-6273(93)90145-h · Cited by 835
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688
Directionally selective calcium signals in dendrites of starburst amacrine cells
Euler, T., Detwiler, P. B., & Denk, W. (2002) · Nature · doi:10.1038/nature00931 · Cited by 587
Fon, E. A., Pothos, E. N., Sun, B.-C., Killeen, N., Sulzer, D., & Edwards, R. H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80418-3 · Cited by 337
Ion channel expression by white matter glia: The O-2A glial progenitor cell
Barres, B. A., Koroshetz, W. J., Swartz, K. J., Chun, L. L. Y., & Corey, D. P. (1990) · Neuron · doi:10.1016/0896-6273(90)90109-s · Cited by 301
Metadata
- Authors
- Schwartz, E. A.
- Venue
- Science
- Published
- 1987-10-16
- Volume
- 238
- Issue
- 4825
- Pages
- 350-355
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026447477
- Cited by
- 344
- References
- 0
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwartz, E. A. (1987). Depolarization Without Calcium Can Release γ-Aminobutyric Acid from a Retinal Neuron. Science. https://doi.org/10.1126/science.2443977
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