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Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity
Abstract
Abnormal functional activity induces long-lasting physiological alterations in neural pathways that may play a role in the development of epilepsy. The cellular mechanisms of these alterations are not well understood. One hypothesis is that abnormal activity causes structural reorganization of neural pathways and promotes epileptogenesis. This report provides morphological evidence that synchronous perforant path activation and kindling of limbic pathways induce axonal growth and synaptic reorganization in the hippocampus, in the absence of overt morphological damage. The results show a previously unrecognized anatomic plasticity associated with synchronous activity and development of epileptic seizures in neural pathways.
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Cited by
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i · Cited by 3,441
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
Isackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711
Cellular and molecular basis of epilepsy
McNamara, J. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03413.1994 · Cited by 649
Metadata
- Authors
- Sutula, T., He, X.-X., Cavazos, J., & Scott, G.
- Venue
- Science
- Published
- 1988-03-04
- Volume
- 239
- Issue
- 4844
- Pages
- 1147-1150
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077369265
- Cited by
- 902
- References
- 0
- FWCI
- 30.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sutula, T., He, X.-X., Cavazos, J., & Scott, G. (1988). Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity. Science. https://doi.org/10.1126/science.2449733
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