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Cl - Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase
Abstract
Secretory chloride channels can be activated by adenosine 3′,5′-monophosphate (cAMP)-dependent protein kinase in normal airway epithelial cells but not in cells from individuals with cystic fibrosis (CF). In excised, inside-out patches of apical membrane of normal human airway cells and airway cells from three patients with CF, the chloride channels exhibited a characteristic outwardly rectifying current-voltage relation and depolarization-induced activation. Channels from normal tissues were activated by both cAMP-dependent protein kinase and protein kinase C. However, chloride channels from CF patients could not be activated by either kinase. Thus, gating of normal epithelial chloride channels is regulated by both cAMP-dependent protein kinase and protein kinase C, and regulation by both kinases is defective in CF.
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Cited by
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Defective acidification of intracellular organelles in cystic fibrosis
Barasch, J., Kiss, B., Prince, A., Saiman, L., Gruenert, D., & AI-Awqati, Q. (1991) · Nature · doi:10.1038/352070a0 · Cited by 490
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Metadata
- Authors
- Hwang, T.-C., Lu, L., Zeitlin, P. L., Gruenert, D. C., Huganir, R., & Guggino, W. B.
- Venue
- Science
- Published
- 1989-06-16
- Volume
- 244
- Issue
- 4910
- Pages
- 1351-1353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042305464
- Cited by
- 263
- References
- 0
- FWCI
- 68.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hwang, T.-C., Lu, L., Zeitlin, P. L., Gruenert, D. C., Huganir, R., & Guggino, W. B. (1989). Cl - Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase. Science. https://doi.org/10.1126/science.2472005
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