The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
Abstract
Complementary DNA's that encode an adenylyl cyclase were isolated from a bovine brain library. Most of the deduced amino acid sequence of 1134 residues is divisible into two alternating sets of hydrophobic and hydrophilic domains. Each of the two large hydrophobic domains appears to contain six transmembrane spans. Each of the two large hydrophilic domains contains a sequence that is homologous to a single cytoplasmic domain of several guanylyl cyclases; these sequences may represent nucleotide binding sites. An unexpected topographical resemblance between adenylyl cyclase and various plasma membrane channels and transporters was observed. This structural complexity suggests possible, unappreciated functions for this important enzyme.
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Cites
Livingstone, M. S., Sziber, P. P., & Quinn, W. G. (1984) · Cell · doi:10.1016/0092-8674(84)90316-7 · Cited by 587
Cited by
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
Tang, W.-J., & Gilman, A. G. (1991) · Science · doi:10.1126/science.1962211 · Cited by 1,091
Self-citationComplexity and Diversity of Mammalian Adenylyl Cyclases
Sunahara, R. K., Dessauer, C. W., & Gilman, A. G. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.002333 · Cited by 874
Self-citationMammalian Membrane-bound Adenylyl Cyclases
Taussig, R., & Gilman, A. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.1 · Cited by 721
Self-citationIdentification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection
Bakalyar, H. A., & Reed, R. R. (1990) · Science · doi:10.1126/science.2255909 · Cited by 694
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Metadata
- Authors
- Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W.-J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R., & Gilman, A. G.
- Venue
- Science
- Published
- 1989-06-30
- Volume
- 244
- Issue
- 4912
- Pages
- 1558-1564
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965447347
- Cited by
- 738
- References
- 1
- FWCI
- 26.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W.-J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R., & Gilman, A. G. (1989). Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure. Science. https://doi.org/10.1126/science.2472670
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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