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The Product of the mos Proto-Oncogene as a Candidate "Initiator" for Oocyte Maturation
Abstract
The endogenous c- mos product, pp39 mos , is required for progesterone-induced meiotic maturation in Xenopus oocytes. Treatment of oocytes with progesterone induced a rapid increase in pp39 mos that preceded both the activation of maturation promoting factor (MPF) and germinal vesicle breakdown (GVBD). Microinjection of synthetic mos RNA into oocytes activated MPF and induced GVBD in the absence of progesterone. Thus, the mos proto-oncogene product may qualify as a candidate "initiator" protein of MPF and is at least one of the "triggers" for G 2 to M transition.
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Citations
Cited by
Cytoplasmic Polyadenylation in Development and Beyond
Richter, J. D. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.446-456.1999 · Cited by 299
Gebauer, F., Xu, W., Cooper, G. M., & Richter, J. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06909.x · Cited by 235
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
Vitale, I., Senovilla, L., Jemaà, M., Michaud, M., Galluzzi, L., Kepp, O., Nanty, L., Criollo, A., Rello‐Varona, S., Manic, G., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.11 · Cited by 146
Meiotic maturation in Xenopus requires polyadenylation of multiple mRNAs
Barkoff, A., Ballantyne, S., & Wickens, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3168 · Cited by 93
Metadata
- Authors
- Sagata, N., Daar, I., Oskarsson, M., Showalter, S. D., & Vande Woude, G. F.
- Venue
- Science
- Published
- 1989-08-11
- Volume
- 245
- Issue
- 4918
- Pages
- 643-646
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012781224
- Cited by
- 336
- References
- 0
- FWCI
- 43.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sagata, N., Daar, I., Oskarsson, M., Showalter, S. D., & Vande Woude, G. F. (1989). The Product of the mos Proto-Oncogene as a Candidate "Initiator" for Oocyte Maturation. Science. https://doi.org/10.1126/science.2474853
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
