The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Treatment with Tin Prevents the Development of Hypertension in Spontaneously Hypertensive Rats
Abstract
Cytochrome P-450-dependent metabolites of arachidonic acid (AA) increased in the kidneys of young, spontaneously hypertensive rats (SHRs) during the period of rapid elevation of blood pressure (BP) but not in adult SHRs or in Wistar Kyoto rats (WKYs) with normal BP. Treatment of SHRs and WKYs with stannous chloride (SnCl 2 ), which selectively depletes renal cytochrome P-450, restored BP to normal, coincident with a natriuresis, in young but not in adult SHRs and did not affect either BP or sodium excretion in WKYs. Depletion of renal cytochrome P-450 was associated with decreased generation of these AA metabolites only in young SHRs. The antihypertensive effect of SnCl 2 in young SHRs was greatly reduced by prevention of its cytochrome P-450-depleting action.
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Cites
The Carbon Monoxide-binding Pigment of Liver Microsomes
Omura, T., & Sato, R. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82244-3 · Cited by 11,781
Development of a Strain of Spontaneously Hypertensive Rats
OKAMOTO, K., & AOKI, K. (1963) · Japanese Circulation Journal · doi:10.1253/jcj.27.282 · Cited by 2,545
Cited by
P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function
Roman, R. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00021.2001 · Cited by 1,309
Pharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115
Self-citationCarbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
Lasker, J. M., Chen, W. B., Wolf, I., Bloswick, B. P., Wilson, P. D., & Powell, P. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4118 · Cited by 305
Khoo, N. K. H., Rudolph, V., Cole, M. P., Golin-Bisello, F., Schopfer, F. J., Woodcock, S. R., Batthyany, C., & Freeman, B. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.046 · Cited by 79
Metadata
- Authors
- Sacerdoti, D., Escalante, B., Abraham, N. G., McGiff, J. C., Levere, R. D., & Schwartzman, M. L.
- Venue
- Science
- Published
- 1989-01-20
- Volume
- 243
- Issue
- 4889
- Pages
- 388-390
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072724629
- Cited by
- 278
- References
- 2
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sacerdoti, D., Escalante, B., Abraham, N. G., McGiff, J. C., Levere, R. D., & Schwartzman, M. L. (1989). Treatment with Tin Prevents the Development of Hypertension in Spontaneously Hypertensive Rats. Science. https://doi.org/10.1126/science.2492116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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