The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite
Abstract
C/EBP is a rat liver nuclear protein capable of sequence-specific interaction with DNA. The DNA sequences to which C/EBP binds in vitro have been implicated in the control of messenger RNA synthesis. It has therefore been predicted that C/EBP will play a role in regulating gene expression in mammalian cells. The region of the C/EBP polypeptide required for direct interaction with DNA has been identified and shown to bear amino acid sequence relatedness with the product of the myc , fos , and jun proto-oncogenes. The arrangement of these related amino acid sequences led to the prediction of a new structural motif, termed the "leucine zipper," that plays a role in facilitating sequence-specific interaction between protein and DNA. Experimental tests now provide support for the leucine zipper hypothesis.
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Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Self-citation
Cited by
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Self-citationStimulus-transcription coupling in neurons: role of cellular immediate-early genes
Morgan, J. I., & Curran, T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90096-9 · Cited by 969
How Ions Affect the Structure of Water
Hribar, B., Southall, N. T., Vlachy, V., & Dill, K. A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026014h · Cited by 860
Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors
Lekstrom-Himes, J., & Xanthopoulos, K. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28545 · Cited by 801
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
Metadata
- Authors
- Landschulz, W. H., Johnson, P. F., & McKnight, S. L.
- Venue
- Science
- Published
- 1989-03-31
- Volume
- 243
- Issue
- 4899
- Pages
- 1681-1688
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038352589
- Cited by
- 636
- References
- 2
- FWCI
- 32.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1989). The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite. Science. https://doi.org/10.1126/science.2494700
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