The DOI matches its Crossref record.
Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression
Abstract
Transcriptional activation of the human interleukin-2 (IL-2) gene, like induction of the IL-2 receptor α (IL-2Rα) gene and the type 1 human immunodeficiency virus (HIV-1), is shown to be modulated by a κB-like enhancer element. Mutation of a κB core sequence identified in the IL-2 promoter (-206 to -195) partially inhibits both mitogen- and HTLV-I Tax-mediated activation of this transcription unit and blocks the specific binding of two inducible cellular factors. These κB-specific proteins (80 to 90 and 50 to 55 kilodaltons) similarly interact with the functional κB enhancer present in the IL-2Rα promoter. These data suggest that these κB-specific proteins have a role in the coordinate regulation of this growth factor-growth factor receptor gene system that controls T cell proliferation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
Grilli, M., Chiu, J. J.-S., & Lenardo, M. J. (1993) · International Review of Cytology · doi:10.1016/s0074-7696(08)61873-2 · Cited by 936
Shakhov, A. N., Collart, M. A., Vassalli, P., Nedospasov, S. A., & Jongeneel, C. V. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.1.35 · Cited by 819
Inflammation, free radicals, and antioxidants
Conner, E. M., & Grisham, M. B. (1996) · Nutrition · doi:10.1016/s0899-9007(96)00000-8 · Cited by 699
Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28
Fraser, J. D., Irving, B. A., Crabtree, G. R., & Weiss, A. (1991) · Science · doi:10.1126/science.1846244 · Cited by 641
Metadata
- Authors
- Hoyos, B., Ballard, D. W., Böhnlein, E., Siekevitz, M., & Greene, W. C.
- Venue
- Science
- Published
- 1989-04-28
- Volume
- 244
- Issue
- 4903
- Pages
- 457-460
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093939923
- Cited by
- 318
- References
- 0
- FWCI
- 22.14
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression. https://app.cochat.ai/papers/10.1126/science.2497518
- The paper
- Hoyos, B., Ballard, D. W., Böhnlein, E., Siekevitz, M., & Greene, W. C. (1989). Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression. Science. https://doi.org/10.1126/science.2497518
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
