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Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family
Abstract
A complementary DNA (cDNA) for the rat luteal lutropin-choriogonadotropin receptor (LH-CG-R) was isolated with the use of a DNA probe generated in a polymerase chain reaction with oligonucleotide primers based on peptide sequences of purified receptor protein. As would be predicted from the cDNA sequence, the LH-CG-R consists of a 26-residue signal peptide, a 341-residue extracellular domain displaying an internal repeat structure characteristic of members of the leucine-rich glycoprotein (LRG) family, and a 333-residue region containing seven transmembrane segments. This membrane-spanning region displays sequence similarity with all members of the G protein-coupled receptor family. Hence, the LH-CG-R gene may have evolved by recombination of LRG and G protein-coupled receptor genes. Cells engineered to express LH-CG-R cDNA bind human choriogonadotropin with high affinity and show an increase in cyclic adenosine monophosphate when exposed to hormone. As revealed by RNA blot analysis and in situ hybridization, the 4.4-kilobase cognate messenger RNA is prominently localized in the rat ovary.
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Cited by
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits
Federman, A. D., Conklin, B. R., Schrader, K. A., Reed, R. R., & Bourne, H. R. (1992) · Nature · doi:10.1038/356159a0 · Cited by 624
Zhang, F., POUTANEN, M. H., Wilbertz, J. H., & Huhtaniemi, I. T. (2001) · Molecular Endocrinology · doi:10.1210/me.15.1.172 · Cited by 580
Szkudlinski, M. W., Fremont, V., Ronin, C., & Weintraub, B. D. (2002) · Physiological Reviews · doi:10.1152/physrev.00031.2001 · Cited by 458
Krueger, K. E., & Papadopoulos, V. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77217-7 · Cited by 345
Metadata
- Authors
- McFarland, K. C., Sprengel, R., Phillips, H. S., Köhler, M., Rosemblit, N., Nikolics, K., Segaloff, D. L., & Seeburg, P. H.
- Venue
- Science
- Published
- 1989-08-04
- Volume
- 245
- Issue
- 4917
- Pages
- 494-499
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093909923
- Cited by
- 929
- References
- 0
- FWCI
- 33.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family. https://app.cochat.ai/papers/10.1126/science.2502842
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- McFarland, K. C., Sprengel, R., Phillips, H. S., Köhler, M., Rosemblit, N., Nikolics, K., Segaloff, D. L., & Seeburg, P. H. (1989). Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family. Science. https://doi.org/10.1126/science.2502842
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