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Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain
Abstract
The three-dimensional solution structure of a zinc finger nucleic acid binding motif has been determined by nuclear magnetic resonance (NMR) spectroscopy. Spectra of a synthetic peptide corresponding to a single zinc finger from the Xenopus protein Xfin yielded distance and dihedral angle constraints that were used to generate structures from distance geometry and restrained molecular dynamics calculations. The zinc finger is an independently folded domain with a compact globular structure in which the zinc atom is bound by two cysteine and two histidine ligands. The polypeptide backbone fold consists of a well-defined helix, starting as alpha and ending as 3(10) helix, packed against two beta strands that are arranged in a hairpin structure. A high density of basic and polar amino acid side chains on the exposed face of the helix are probably involved in DNA binding.
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Citations
Cited by
Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å
Pavletich, N. P., & Pabo, C. O. (1991) · Science · doi:10.1126/science.2028256 · Cited by 2,061
Zinc finger proteins: new insights into structural and functional diversity
Laity, J. H., Lee, B. M., & Wright, P. E. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00167-6 · Cited by 1,534
Self-citationCrystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991) · Nature · doi:10.1038/352497a0 · Cited by 1,503
DNA Recognition by Cys2His2 Zinc Finger Proteins
Wolfe, S. A., Nekludova, L., & Pabo, C. O. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.183 · Cited by 1,053
Intrinsic Disorder in Transcription Factors
Liu, J., Perumal, N. B., Oldfield, C. J., Su, E. W., Uversky, V. N., & Dunker, A. K. (2006) · Biochemistry · doi:10.1021/bi0602718 · Cited by 792
Metadata
- Authors
- Lee, M. S., Gippert, G. P., Soman, K. V., Case, D. A., & Wright, P. E.
- Venue
- Science
- Published
- 1989-08-11
- Volume
- 245
- Issue
- 4918
- Pages
- 635-637
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030333654
- Cited by
- 627
- References
- 0
- FWCI
- 21.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, M. S., Gippert, G. P., Soman, K. V., Case, D. A., & Wright, P. E. (1989). Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain. Science. https://doi.org/10.1126/science.2503871
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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