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1990: Annus Mirabilis of Potassium Channels
Abstract
Voltage-gated potassium channels make up a large molecular family of integral membrane proteins that are fundamentally involved in the generation of bioelectric signals such as nerve impulses. These proteins span the cell membrane, forming potassium-selective pores that are rapidly switched open or closed by changes in membrane voltage. After the cloning of the first potassium channel over 3 years ago, recombinant DNA manipulation of potassium channel genes is now leading to a molecular understanding of potassium channel behavior. During the past year, functional domains responsible for channel gating and potassium selectivity have been identified, and detailed structural pictures underlying these functions are beginning to emerge.
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Cited by
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Catterall, W. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81133-2 · Cited by 2,118
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Vacher, H., Mohapatra, D. P., & Trimmer, J. S. (2008) · Physiological Reviews · doi:10.1152/physrev.00002.2008 · Cited by 488
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+channel
Lu, Z., & MacKinnon, R. (1994) · Nature · doi:10.1038/371243a0 · Cited by 314
Rojas, C. V., Wang, J., Schwartz, L. S., Hoffman, E. P., Powell, B. R., & Brown Jr, R. H. (1991) · Nature · doi:10.1038/354387a0 · Cited by 313
Crystal structure of the tetramerization domain of the Shaker potassium channel
Kreusch, A., Pfaffinger, P. J., Stevens, C. F., & Choe, S. (1998) · Nature · doi:10.1038/31978 · Cited by 310
Metadata
- Authors
- Miller, C.
- Venue
- Science
- Published
- 1991-05-24
- Volume
- 252
- Issue
- 5009
- Pages
- 1092-1096
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966525549
- Cited by
- 261
- References
- 0
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- closed
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