The DOI matches its Crossref record.
Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes
Abstract
The target of the CD8 + T cell-dependent immunity that protects mice immunized with irradiation-attenuated malaria sporozoites has not been established. Immune BALB/c mice were shown to develop malaria-specific, CD8+ T cell-dependent inflammatory infiltrates in their livers after challenge with Plasmodium berghei sporozoites. Spleen cells from immune BALB/c and C57BL/6 mice eliminated hepatocytes infected with the liver stage of P. berghei in vitro. The activity against infected hepatocytes is not inhibited by antibodies to interferon-γ and is not present in culture supernatants. It is genetically restricted, an indication that malaria antigens on the hepatocyte surface are recognized by immune T effector cells. Subunit vaccine development will require identification of the antigens recognized by these T cells and a method of immunization that induces such immunity.
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Cited by
Protection against malaria at 1 year and immune correlates following PfSPZ vaccination
Ishizuka, A. S., Lyke, K. E., DeZure, A., Berry, A. A., Richie, T. L., Mendoza, F. H., Enama, M. E., Gordon, I. J., Chang, L.-J., Sarwar, U. N., et al. (2016) · Nature Medicine · doi:10.1038/nm.4110 · Cited by 367
Self-citationDoolan, D. L., & Hoffman, S. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.884 · Cited by 183
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Metadata
- Authors
- Hoffman, S. L., Isenbarger, D., Long, G. W., Sedegah, M., Szarfman, A., Waters, L., Hollingdale, M. R., van der Meide, P. H., Finbloom, D. S., & Ballou, W. R.
- Venue
- Science
- Published
- 1989-06-02
- Volume
- 244
- Issue
- 4908
- Pages
- 1078-1081
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999452089
- Cited by
- 178
- References
- 0
- FWCI
- 19.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes. https://app.cochat.ai/papers/10.1126/science.2524877
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- Hoffman, S. L., Isenbarger, D., Long, G. W., Sedegah, M., Szarfman, A., Waters, L., Hollingdale, M. R., van der Meide, P. H., Finbloom, D. S., & Ballou, W. R. (1989). Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes. Science. https://doi.org/10.1126/science.2524877
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
