The DOI matches its Crossref record.
Neurotransmitter Release from Synaptotagmin-Deficient Clonal Variants of PC 12 Cells
Abstract
Synaptotagmin (p65) is an abundant synaptic vesicle protein of neurons and contains regions similar to the regulatory domain of protein kinase C. These domains are thought to be involved in calcium-dependent interaction with membrane phospholipids during exocytosis. To assess the functional role of synaptotagmin, synaptotagmin-deficient clonal variants of PC12 cells were isolated. All of the variant cells released catecholamine and adenosine triphosphate in response to elevated intracellular concentrations of calcium, which suggests that synaptotagmin is not essential for secretion of catecholamine and adenosine triphosphate from PC12 cells.
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Citations
Cited by
Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
Greengard, P., Valtorta, F., Czernik, A. J., & Benfenati, F. (1993) · Science · doi:10.1126/science.8430330 · Cited by 1,312
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Dongré, A. R., Jones, J. L., Somogyi, Á., & Wysocki, V. H. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9542193 · Cited by 894
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
Davletov, B. A., & Südhof, T. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74326-9 · Cited by 480
Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis
Kasai, H., Takahashi, N., & Tokumaru, H. (2012) · Physiological Reviews · doi:10.1152/physrev.00007.2012 · Cited by 150
Metadata
- Authors
- Shoji-Kasai, Y., Yoshida, A., Sato, K., Hoshino, T., Ogura, A., Kondo, S., Fujimoto, Y., Kuwahara, R., Kato, R., & Takahashi, M.
- Venue
- Science
- Published
- 1992-06-26
- Volume
- 256
- Issue
- 5065
- Pages
- 1820-1823
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983955608
- Cited by
- 179
- References
- 0
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shoji-Kasai, Y., Yoshida, A., Sato, K., Hoshino, T., Ogura, A., Kondo, S., Fujimoto, Y., Kuwahara, R., Kato, R., & Takahashi, M. (1992). Neurotransmitter Release from Synaptotagmin-Deficient Clonal Variants of PC 12 Cells. Science. https://doi.org/10.1126/science.256.5065.1820
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