The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Genetic Polymorphism in the Renin Gene of Dahl Rats Cosegregates with Blood Pressure
Abstract
Blood pressure is influenced by multiple genetic loci whose identities are largely unknown. A restriction fragment length polymorphism (RFLP) in the renin gene was found between Dahl salt-hypertension-sensitive (S) and Dahl salt-hypertension-resistant (R) rats. In an F 2 population derived from crossing S and R rats, the renin RFLP cosegregated with blood pressure. One dose of the S-rat renin allele was associated with an increment in blood pressure of approximately 10 mmHg, and two doses of this allele increased blood pressure approximately 20 mmHg. From this it can be definitively concluded that in the rat the renin gene is, or is closely linked to, one of the genes regulating blood pressure.
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Citations
Cites
Development of a Strain of Spontaneously Hypertensive Rats
OKAMOTO, K., & AOKI, K. (1963) · Japanese Circulation Journal · doi:10.1253/jcj.27.282 · Cited by 2,545
Cited by
Regulation of blood pressure by the type 1A angiotensin II receptor gene.
Ito, M., Oliverio, M. I., Mannon, P. J., Best, C. F., Maeda, N., Smithies, O., & Coffman, T. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3521 · Cited by 616
The Promise of Comparative Genomics in Mammals
O'Brien, S. J., Menotti-Raymond, M., Murphy, W. J., Nash, W. G., Wienberg, J., Stanyon, R., Copeland, N. G., Jenkins, N. A., Womack, J. E., & Marshall Graves, J. A. (1999) · Science · doi:10.1126/science.286.5439.458 · Cited by 423
Genetic Analysis of Inherited Hypertension in the Rat
Rapp, J. P. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.135 · Cited by 422
Self-citationGenetics of blood pressure: time to curate the collection
Harrap, S. B., & Charchar, F. J. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001341 · Cited by 2
Metadata
- Authors
- Rapp, J. P., Wang, S.-M., & Dene, H.
- Venue
- Science
- Published
- 1989-01-27
- Volume
- 243
- Issue
- 4890
- Pages
- 542-544
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009085222
- Cited by
- 294
- References
- 1
- FWCI
- 16.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rapp, J. P., Wang, S.-M., & Dene, H. (1989). A Genetic Polymorphism in the Renin Gene of Dahl Rats Cosegregates with Blood Pressure. Science. https://doi.org/10.1126/science.2563177
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