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Cited by 2,834Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntimicrobial Resistance in Staphylococcus

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

The Crisis in Antibiotic Resistance

Neu, Harold C.·1992·Science
DOI 10.1126/science.257.5073.1064
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Abstract

The synthesis of large numbers of antibiotics over the past three decades has caused complacency about the threat of bacterial resistance. Bacteria have become resistant to antimicrobial agents as a result of chromosomal changes or the exchange of the exchange of genetic material via plasmids and transposons. Streptococcus pneumoniae, Streptococcus pyogenes, and staphylococci, organisms that cause respiratory and cutaneous infections, and members of the Enterobacteriaceae and Pseudomonas families, organisms that cause diarrhea, urinary infection, and sepsis, are now resistant to virtually all of the older antibiotics. The extensive use of antibiotics in the community and hospitals has fueled this crisis. Mechanisms such as antibiotic control programs, better hygiene, and synthesis of agents with improved antimicrobial activity need to be adopted in order to limit bacterial resistance.

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Crossref · 10.1126/science.257.5073.1064

Cites

111 of 111 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 109 references

Research works printed but not linked: 30

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Metadata

Authors
Neu, H. C.
Affiliations
Columbia University (US)
Corresponding author
Neu, Harold C.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1992-08-21
Volume
257
Issue
5073
Pages
1064-1073
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.257.5073.1064
OpenAlex
W1980595924
Cited by
2,834
References
109
Citations by year
2026: 23 · 2025: 48 · 2024: 57 · 2023: 71 · 2022: 91 · 2021: 93 · 2020: 123 · 2019: 100 · 2018: 122 · 2017: 123 · 2016: 105 · 2015: 87 · 2014: 95 · 2013: 109 · 2012: 99
FWCI
46.70
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
antibiotic resistance, bacterial resistance, plasmids, transposable elements, horizontal gene transfer, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus, Enterobacteriaceae, Pseudomonas, antibiotic overuse, hygiene, novel antimicrobial agents
MeSH terms
Anti-Bacterial Agents, Bacterial Infections, Cross Infection, Drug Resistance, Microbial, Enterobacteriaceae, Haemophilus influenzae, Humans, Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus

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