The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An Animal Model for Cystic Fibrosis Made by Gene Targeting
Abstract
Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-dependent chloride ion channel known as the cystic fibrosis transmembrane conductance regulator (CFTR). To create an animal model for cystic fibrosis, mice were generated from embryonic stem cells in which the CFTR gene was disrupted by gene targeting. Mice homozygous for the disrupted gene display many features common to young human cystic fibrosis patients, including failure to thrive, meconium ileus, alteration of mucous and serous glands, and obstruction of glandlike structures with inspissated eosinophilic material. Death resulting from intestinal obstruction usually occurs before 40 days of age.
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Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Identification of the Cystic Fibrosis Gene: Genetic Analysis
Kerem, B.-S., Rommens, J. M., Buchanan, J. A., Markiewicz, D., Cox, T. K., Chakravarti, A., Buchwald, M., & Tsui, L.-C. (1989) · Science · doi:10.1126/science.2570460 · Cited by 4,142
Cited by
Cystic fibrosis genetics: from molecular understanding to clinical application
Cutting, G. R. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3849 · Cited by 965
Notch1 is essential for postimplantation development in mice.
Swiatek, P. J., Lindsell, C. E., del Amo, F. F., Weinmaster, G., & Gridley, T. (1994) · Genes & Development · doi:10.1101/gad.8.6.707 · Cited by 734
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Chao, A. C., de Sauvage, F. J., Dong, Y. J., Wagner, J. A., Goeddel, D. V., & Gardner, P. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06355.x · Cited by 273
Wu, C.-L., & Melton, D. W. (1993) · Nature Genetics · doi:10.1038/ng0393-235 · Cited by 101
Metadata
- Authors
- Snouwaert, J. N., Brigman, K. K., Latour, A. M., Malouf, N. N., Boucher, R. C., Smithies, O., & Koller, B. H.
- Venue
- Science
- Published
- 1992-08-21
- Volume
- 257
- Issue
- 5073
- Pages
- 1083-1088
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013306854
- Cited by
- 918
- References
- 2
- FWCI
- 61.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Snouwaert, J. N., Brigman, K. K., Latour, A. M., Malouf, N. N., Boucher, R. C., Smithies, O., & Koller, B. H. (1992). An Animal Model for Cystic Fibrosis Made by Gene Targeting. Science. https://doi.org/10.1126/science.257.5073.1083
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
