The DOI matches its Crossref record.
AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects
Abstract
When grown in vitro, cells from Kaposi's sarcoma lesions of AIDS patients (AIDS-KS cells) constitutively release several growth promoting activities. When inoculated into nude mice, the AIDS-KS cells induce a KS-like lesion of mouse origin. Here it is shown that the AIDS-KS cells express messenger RNA for a complex mixture of cytokines that correlate with several of the biological activities of these cells. Basic fibroblast growth factor, which is a potent angiogenic factor, and interleukin-1 messenger RNAs are expressed at very high levels and seem to account for a large proportion of the activities, since their corresponding proteins are released in biologically active form into the culture media where they induce autocrine and paracrine growth effects.
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Cited by
Uldrick, T. S., Wang, V., O’Mahony, D., Aleman, K., Wyvill, K. M., Marshall, V., Steinberg, S. M., Pittaluga, S., Maric, I., Whitby, D., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/654798 · Cited by 304
Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis
Lieu, C., Heymach, J., Overman, M., Tran, H., & Kopetz, S. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0659 · Cited by 286
Buonaguro, L., Barillari, G., Chang, H. K., Bohan, C. A., Kao, V, Morgan, R., Gallo, R. C., & Ensoli, B. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.7159-7167.1992 · Cited by 277
Self-citationInterferon-alpha and its effects on the cytokine cascade: a pro- and anti-inflammatory cytokine
Tilg, H., & Peschel, C. (1996) · Leukemia & Lymphoma · doi:10.3109/10428199609054802 · Cited by 34
Metadata
- Authors
- Ensoli, B., Nakamura, S., Salahuddin, S. Z., Biberfeld, P., Larsson, L., Beaver, B., Wong-Staal, F., & Gallo, R. C.
- Venue
- Science
- Published
- 1989-01-13
- Volume
- 243
- Issue
- 4888
- Pages
- 223-226
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036830225
- Cited by
- 460
- References
- 0
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects. https://app.cochat.ai/papers/10.1126/science.2643161
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- Ensoli, B., Nakamura, S., Salahuddin, S. Z., Biberfeld, P., Larsson, L., Beaver, B., Wong-Staal, F., & Gallo, R. C. (1989). AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects. Science. https://doi.org/10.1126/science.2643161
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
