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The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes
Abstract
T lymphocyte chemotactic factor (TCF) was purified to homogeneity from the conditioned media of phytohemagglutinin-stimulated human blood mononuclear leukocytes by a sequence of chromatography procedures. The amino-terminal amino acid sequence of the purified TCF showed identity with neutrophil-activating protein (NAP-1). Both TCF and recombinant NAP-1 (rNAP-1) were chemotactic for neutrophils and T lymphocytes in vitro supporting the identity of TCF with NAP-1. Injection of rNAP-1 into lymphatic drainage areas of lymph nodes in Fisher rats caused accelerated emigration of only lymphocytes in high endothelial venules. Intradermal injection of rNAP-1 caused dose-dependent accumulation of neutrophils and lymphocytes.
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Cited by
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Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
Schall, T. J., Bacon, K., Toy, K. J., & Goeddel, D. V. (1990) · Nature · doi:10.1038/347669a0 · Cited by 1,379
Inflammation and cancer: advances and new agents
Crusz, S. M., & Balkwill, F. R. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.105 · Cited by 1,184
Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.
Carr, M. W., Roth, S. J., Luther, E., Rose, S. S., & Springer, T. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3652 · Cited by 1,198
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Metadata
- Authors
- Larsen, C. G., Anderson, A. O., Appella, E., Oppenheim, J. J., & Matsushima, K.
- Venue
- Science
- Published
- 1989-03-17
- Volume
- 243
- Issue
- 4897
- Pages
- 1464-1466
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983239749
- Cited by
- 1,038
- References
- 0
- FWCI
- 36.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Larsen, C. G., Anderson, A. O., Appella, E., Oppenheim, J. J., & Matsushima, K. (1989). The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes. Science. https://doi.org/10.1126/science.2648569
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
