The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins
Abstract
C/EBP is a sequence-specific DNA binding protein that regulates gene expression in certain mammalian cells. The region of the C/EBP polypeptide required for specific recognition of DNA is related in amino acid sequence to other regulatory proteins, including the Fos and Jun transforming proteins. It has been proposed that these proteins bind DNA via a bipartite structural motif, consisting of a dimerization interface termed the "leucine zipper" and a DNA contact surface termed the "basic region." An evaluation of the properties of conserved amino acids within the basic region of 11 deduced protein sequences, coupled with the observation that they are located at an invariant distance from the leucine zipper, has led to the formulation of a "scissors-grip" model for DNA binding. The architectural features of this model are well suited for interaction with directly abutted, dyadsymmetric DNA sequences. Data supportive of the model were obtained with chemical probes of protein: DNA complexes.
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Citations
Cites
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Self-citationJohnson, P. F., Landschulz, W. H., Graves, B. J., & McKnight, S. L. (1987) · Genes & Development · doi:10.1101/gad.1.2.133 · Cited by 595
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Cited by
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Self-citationRedox Regulation of Fos and Jun DNA-Binding Activity in Vitro
Abate, C., Patel, L., Rauscher, F. J., & Curran, T. (1990) · Science · doi:10.1126/science.2118682 · Cited by 1,573
Yu, V. C., Delsert, C., Andersen, B., Holloway, J. M., Devary, O. V., Näär, A. M., Kim, S. Y., Boutin, J.-M., Glass, C. K., & Rosenfeld, M. G. (1991) · Cell · doi:10.1016/0092-8674(91)90301-e · Cited by 1,205
Descombes, P., & Schibler, U. (1991) · Cell · doi:10.1016/0092-8674(91)90531-3 · Cited by 990
Metadata
- Authors
- Vinson, C. R., Sigler, P. B., & McKnight, S. L.
- Venue
- Science
- Published
- 1989-11-17
- Volume
- 246
- Issue
- 4932
- Pages
- 911-916
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008570049
- Cited by
- 1,000
- References
- 2
- FWCI
- 33.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vinson, C. R., Sigler, P. B., & McKnight, S. L. (1989). Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins. Science. https://doi.org/10.1126/science.2683088
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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