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Cited by 333Immunotoxicology and immune responsesImmunotherapy and Immune ResponsesPharmacovigilance and Adverse Drug Reactions

The DOI matches its Crossref record.

Clinical Trials: IL-12 Deaths: Explanation and a Puzzle

Cohen, J.·1995·Science
DOI 10.1126/science.270.5238.908a
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Abstract

Researchers investigating toxic reactions that killed two patients in a trial of interleukin-12 earlier this year have reached a surprising conclusion: The drug is highly toxic if it is given in multiple high doses, but those effects can be avoided if the multiple doses are preceded by a single dose followed by a rest period. The initial dose apparently imprints a memory on the immune system, but the mechanism is unclear.

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Metadata

Authors
Cohen, J.
Corresponding author
Cohen, J.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-11-10
Volume
270
Issue
5238
Pages
908a-908
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.270.5238.908a
OpenAlex
W1609710757
Cited by
332
References
0
Citations by year
2026: 2 · 2025: 8 · 2024: 15 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 16 · 2019: 15 · 2018: 8 · 2017: 9 · 2016: 15 · 2015: 8 · 2014: 5 · 2013: 13 · 2012: 15
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Keywords
IL-12, drug toxicity, dose scheduling, immunological memory, cytokine therapy
MeSH terms
Animals, Carcinoma, Renal Cell, Clinical Trials as Topic, Drug Administration Schedule, Humans, Kidney Neoplasms, Macaca fascicularis, Recombinant Proteins, United States, United States Food and Drug Administration, Multicenter Studies as Topic, Th1 Cells, Th2 Cells, Interleukin-12, Mice

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CoChat. (2026). Citation check: Clinical Trials: IL-12 Deaths: Explanation and a Puzzle. https://app.cochat.ai/papers/10.1126/science.270.5238.908a
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Cohen, J. (1995). Clinical Trials: IL-12 Deaths: Explanation and a Puzzle. Science. https://doi.org/10.1126/science.270.5238.908a