The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Solution Structure of a Cisplatin-Induced DNA Interstrand Cross-Link
Abstract
The widely used antitumor drug cis -diamminedichloroplatinum(II) (cisplatin or cis -DDP) reacts with DNA, cross-linking two purine residues through the N7 atoms, which reside in the major groove in B-form DNA. The solution structure of the short duplex [d(CATAGCTATG)] 2 cross-linked at the GC:GC site was determined by nuclear magnetic resonance (NMR). The deoxyguanosine-bridging cis -diammineplatinum(II) lies in the minor groove, and the complementary deoxycytidines are extrahelical. The double helix is locally reversed to a left-handed form, and the helix is unwound and bent toward the minor groove. These findings were independently confirmed by results from a phase-sensitive gel electrophoresis bending assay. The NMR structure differs markedly from previously proposed models but accounts for the chemical reactivity, the unwinding, and the bending of cis -DDP interstrand cross-linked DNA and may be important in the formation and repair of these cross-links in chromatin.
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Cites
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Left-Handed Double Helical DNA: Variations in the Backbone Conformation
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Cited by
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Cisplatin: From DNA damage to cancer chemotherapy
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DNA Cross-Linking Agents as Antitumor Drugs
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Formation and Repair of Interstrand Cross-Links in DNA
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Metadata
- Authors
- Huang, H., Zhu, L., Reid, B. R., Drobny, G. P., & Hopkins, P. B.
- Venue
- Science
- Published
- 1995-12-15
- Volume
- 270
- Issue
- 5243
- Pages
- 1842-1845
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034742750
- Cited by
- 314
- References
- 19
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, H., Zhu, L., Reid, B. R., Drobny, G. P., & Hopkins, P. B. (1995). Solution Structure of a Cisplatin-Induced DNA Interstrand Cross-Link. Science. https://doi.org/10.1126/science.270.5243.1842
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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