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Reduction of HIV Concentration During Acute Infection: Independence from a Specific Immune Response
Abstract
After infection with the human immunodeficiency virus (HIV), the concentration of the virus in the person's plasma increases. The subsequent decrease in concentration a few weeks later was thought to result from an HIV-specific immune response. This purported causal relation is investigated with a model of the dynamics of early HIV infection that incorporates no increase in the rate of removal of free virions or virus-infected cells. A pattern of changes in virus concentration similar to that observed in patients is predicted by the model. Thus, the reduction in virus concentration during acute infection may not reflect the ability of the HIV-specific immune response to control virus replication.
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Cited by
Goonetilleke, N., Liu, M. K. P., Salazar-Gonzalez, J. F., Ferrari, G., Giorgi, E., Ganusov, V. V., Keele, B. F., Learn, G. H., Turnbull, E. L., Salazar, M. G., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090365 · Cited by 641
Nowak, M. A., Lloyd, A. L., Vasquez, G. M., Wiltrout, T. A., Wahl, L. M., Bischofberger, N., Williams, J., Kinter, A., Fauci, A. S., Hirsch, V. M., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.10.7518-7525.1997 · Cited by 284
Parasite adaptations to within-host competition
Mideo, N. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.03.001 · Cited by 266
Metadata
- Authors
- Phillips, A. N.
- Venue
- Science
- Published
- 1996-01-26
- Volume
- 271
- Issue
- 5248
- Pages
- 497-499
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013602955
- Cited by
- 328
- References
- 0
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Phillips, A. N. (1996). Reduction of HIV Concentration During Acute Infection: Independence from a Specific Immune Response. Science. https://doi.org/10.1126/science.271.5248.497
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
