The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage
Abstract
Most nonmalignant cells are anchorage-dependent; they require substrate attachment for growth and, in some instances, survival. This requirement is lost on oncogenic transformation. The cyclin E-CDK2 complex, which is required for the G 1 -S transition of the cell cycle, was activated in late G 1 phase in attached human fibroblasts, but not in fibroblasts maintained in suspension. In transformed fibroblasts the complex was active regardless of attachment. The lack of cyclin E-CDK2 activity in suspended cells appeared to result from increased expression of CDK2 inhibitors and a concomitant decrease in phosphorylation of CDK2 on threonine-160. Suppression of cyclin E-CDK2 activity may thus underlie the anchorage dependence of cell growth.
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Citations
Cites
Role of cell shape in growth control
Folkman, J., & Moscona, A. (1978) · Nature · doi:10.1038/273345a0 · Cited by 2,422
Cited by
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
Cyclin E-CDK2 is a regulator of p27Kip1.
Sheaff, R. J., Groudine, M., Gordon, M., Roberts, J. M., & Clurman, B. E. (1997) · Genes & Development · doi:10.1101/gad.11.11.1464 · Cited by 911
Aplin, A. E., Howe, A., Alahari, S. K., & Juliano, R. L. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01359-0 · Cited by 847
The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression
Wary, K. K., Mainiero, F., Isakoff, S. J., Marcantonio, E. E., & Giancotti, F. G. (1996) · Cell · doi:10.1016/s0092-8674(00)81392-6 · Cited by 731
Metadata
- Authors
- Fang, F., Orend, G., Watanabe, N., Hunter, T., & Ruoslahti, E.
- Venue
- Science
- Published
- 1996-01-26
- Volume
- 271
- Issue
- 5248
- Pages
- 499-502
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035641694
- Cited by
- 361
- References
- 1
- FWCI
- 23.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fang, F., Orend, G., Watanabe, N., Hunter, T., & Ruoslahti, E. (1996). Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage. Science. https://doi.org/10.1126/science.271.5248.499
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
