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Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
Abstract
The CD44 family of surface receptors regulates adhesion, movement, and activation of normal and neoplastic cells. The cytokine osteopontin (Eta-1), which regulates similar cellular functions, was found to be a protein ligand of CD44. Osteopontin induces cellular chemotaxis but not homotypic aggregation, whereas the inverse is true for the interaction between CD44 and a carbohydrate ligand, hyaluronate. The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth. This mechanism may also be exploited by tumor cells to promote metastasis formation.
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Citations
Cited by
The biology and role of CD44 in cancer progression: Therapeutic implications
Chen, C., Zhao, S., Karnad, A., & Freeman, J. W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0605-5 · Cited by 1,245
Osteopontin: role in immune regulation and stress responses
Wang, K. X., & Denhardt, D. T. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.001 · Cited by 669
The cell biology of bone metabolism
Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048868 · Cited by 614
Rittling, S. R., Matsumoto, H. N., Mckee, M. D., Nanci, A., An, X.-R., Novick, K. E., Kowalski, A. J., Noda, M., & Denhardt, D. T. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.7.1101 · Cited by 438
CD44 as a tumor biomarker and therapeutic target
Xu, H., Niu, M., Yuan, X., Wu, K., & Liu, A. (2020) · Experimental Hematology & Oncology · doi:10.1186/s40164-020-00192-0 · Cited by 389
Metadata
- Authors
- Weber, G. F., Ashkar, S., Glimcher, M. J., & Cantor, H.
- Venue
- Science
- Published
- 1996-01-26
- Volume
- 271
- Issue
- 5248
- Pages
- 509-512
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077569218
- Cited by
- 949
- References
- 0
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weber, G. F., Ashkar, S., Glimcher, M. J., & Cantor, H. (1996). Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1). Science. https://doi.org/10.1126/science.271.5248.509
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
