The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER
Abstract
Genetic studies indicated that the Drosophila melanogaster protein REAPER (RPR) controls apoptosis during embryo development. Induction of RPR expression in Drosophila Schneider cells rapidly stimulated apoptosis. RPR-mediated apoptosis was blocked by N -benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk), which suggests that an interleukin-1β converting enzyme (ICE)-like protease is required for RPR function. RPR-induced apoptosis was associated with increased ceramide production that was also blocked by Z-VAD-fmk, which suggests that ceramide generation requires an ICE-like protease as well. Thus, the intracellular RPR protein uses cell death signaling pathways similar to those used by the vertebrate transmembrane receptors Fas (CD95) and tumor necrosis factor receptor type 1.
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Cites
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
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Programmed Cell Death Induced by Ceramide
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Protease activation during apoptosis: Death by a thousand cuts?
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Cited by
Caspases: the executioners of apoptosis
COHEN, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,719
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
Functions of Ceramide in Coordinating Cellular Responses to Stress
Hannun, Y. A. (1996) · Science · doi:10.1126/science.274.5294.1855 · Cited by 1,617
Mitochondrial permeability transition is a central coordinating event of apoptosis.
Marchetti, P., Castedo, M., Susin, S. A., Zamzami, N., Hirsch, T., Macho, A., Haeffner, A., Hirsch, F., Geuskens, M., & Kroemer, G. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1155 · Cited by 847
Metadata
- Authors
- Pronk, G. J., Ramer, K., Amiri, P., & Williams, L. T.
- Venue
- Science
- Published
- 1996-02-09
- Volume
- 271
- Issue
- 5250
- Pages
- 808-810
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095335458
- Cited by
- 256
- References
- 38
- FWCI
- 20.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pronk, G. J., Ramer, K., Amiri, P., & Williams, L. T. (1996). Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER. Science. https://doi.org/10.1126/science.271.5250.808
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
