The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Heparin Structure and Interactions with Basic Fibroblast Growth Factor
Abstract
Crystal structures of heparin-derived tetra- and hexasaccharides complexed with basic fibroblast growth factor (bFGF) were determined at resolutions of 1.9 and 2.2 angstroms, respectively. The heparin structure may be approximated as a helical polymer with a disaccharide rotation of 174° and a translation of 8.6 angstroms along the helix axis. Both molecules bound similarly to a region of the bFGF surface containing residues asparagine-28, arginine-121, lysine-126, and glutamine-135; the hexasaccharide also interacted with an additional binding site formed by lysine-27, asparagine-102, and lysine-136. No significant conformational change in bFGF occurred upon heparin oligosaccharide binding, which suggests that heparin primarily serves to juxtapose components of the FGF signal transduction pathway.
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Citations
Cites
Specific heparan sulfate saccharides mediate the activity of basic fibroblast growth factor.
Walker, A., Turnbull, J. E., & Gallagher, J. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42201-0 · Cited by 200
Cited by
Fibroblast growth factors, their receptors and signaling
Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332
Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., & Mohammadi, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00073-3 · Cited by 1,199
Self-citationHeparin and heparan sulfate: Structure and function
Rabenstein, D. L. (2002) · Natural Product Reports · doi:10.1039/b100916h · Cited by 870
Demystifying Heparan Sulfate–Protein Interactions
Xu, D., & Esko, J. D. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035314 · Cited by 805
Regulated Diversity of Heparan Sulfate
Lindahl, U., Kusche-Gullberg, M., & Kjellén, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.24979 · Cited by 678
Metadata
- Authors
- Faham, S., Hileman, R. E., Fromm, J. R., Linhardt, R. J., & Rees, D. C.
- Venue
- Science
- Published
- 1996-02-23
- Volume
- 271
- Issue
- 5252
- Pages
- 1116-1120
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965144118
- Cited by
- 798
- References
- 1
- FWCI
- 17.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Faham, S., Hileman, R. E., Fromm, J. R., Linhardt, R. J., & Rees, D. C. (1996). Heparin Structure and Interactions with Basic Fibroblast Growth Factor. Science. https://doi.org/10.1126/science.271.5252.1116
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
