The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor
Abstract
The adenovirus E4orf6 protein is shown here to interact with the cellular tumor suppressor protein p53 and to block p53-mediated transcriptional activation. The adenovirus protein inhibited the ability of p53 to bind to human TAF II 31, a component of transcription factor IID (TFIID). Earlier work demonstrated that the interaction of p53 with TAF II 31 involves a sequence near the NH 2 -terminus of p53, whereas the E4orf6-p53 interaction occurs within amino acids 318 to 360 of p53. Thus, the E4orf6 protein interacts at a site on p53 distinct from the domain that binds to TAF II 31 but nevertheless inhibits the p53-TAF II 31 interaction.
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Cites
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Cited by
An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells
Bischoff, J. R., Kirn, D. H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., Nye, J. A., Sampson-Johannes, A., Fattaey, A., et al. (1996) · Science · doi:10.1126/science.274.5286.373 · Cited by 1,760
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Self-citationRecent lessons in gene expression, cell cycle control, and cell biology from adenovirus
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The Landscape of Human Proteins Interacting with Viruses and Other Pathogens
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p53-Independent and -Dependent Requirements for E1B-55K in Adenovirus Type 5 Replication
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Metadata
- Authors
- Dobner, T., Horikoshi, N., Rubenwolf, S., & Shenk, T.
- Venue
- Science
- Published
- 1996-06-07
- Volume
- 272
- Issue
- 5267
- Pages
- 1470-1473
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978834861
- Cited by
- 311
- References
- 36
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dobner, T., Horikoshi, N., Rubenwolf, S., & Shenk, T. (1996). Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor. Science. https://doi.org/10.1126/science.272.5267.1470
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
