The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus
Abstract
Drosophila limb development is organized by interactions between anterior and posterior compartment cells. Posterior cells continuously express and require engrailed ( en ) and secrete Hedgehog (Hh) protein. Anterior cells express the zinc-finger protein Cubitus interruptus (Ci). It is now shown that anterior cells lacking ci express hh and adopt posterior properties without expressing en . Increased levels of Ci can induce the expression of the Hh target gene decapentaplegic ( dpp ) in a Hh-independent manner. Thus, expression of Ci in anterior cells controls limb development (i) by restricting hh secretion to posterior cells and (ii) by conferring competence to respond to Hh by mediating the transduction of this signal.
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Citations
Cites
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
Petrif, F., Giles, R. H., Dauwerse, H. G., Saris, J. J., Hennekam, R. C. M., Masuno, M., Tommerup, N., van Ommen, G.-J. B., Goodman, R. H., Peters, D. J. M., et al. (1995) · Nature · doi:10.1038/376348a0 · Cited by 1,217
Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Cited by
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
The segment polarity network is a robust developmental module
von Dassow, G., Meir, E., Munro, E. M., & Odell, G. M. (2000) · Nature · doi:10.1038/35018085 · Cited by 1,144
Sasaki, H., Nishizaki, Y., Hui, C.-C., Nakafuku, M., & Kondoh, H. (1999) · Development · doi:10.1242/dev.126.17.3915 · Cited by 715
Grove, E. A., Tole, S., Limon, J., Yip, L.-W., & Ragsdale, C. W. (1998) · Development · doi:10.1242/dev.125.12.2315 · Cited by 587
Metadata
- Authors
- Domínguez, M., Brunner, M., Hafen, E., & Basler, K.
- Venue
- Science
- Published
- 1996-06-14
- Volume
- 272
- Issue
- 5268
- Pages
- 1621-1625
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009261781
- Cited by
- 318
- References
- 2
- FWCI
- 15.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Domínguez, M., Brunner, M., Hafen, E., & Basler, K. (1996). Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus. Science. https://doi.org/10.1126/science.272.5268.1621
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